Vitamin B12 > for food, dietary supplements and beverages

Physiological importance

Vitamin B12 (Cobalamin) is a collective term for compounds which have a cobalt atom in the centre of a porphyrin-type ring system, but different substituents. Vitamin B12 is responsible for degradation of certain fatty acids and amino acids. It plays an important role for the methyl group transfer in the synthesis of amino acids. Therefore, vitamin B12 is important during the synthesis of nucleic acids and proteins. It plays an important role in growth and development processes. Gastric intrinsic factor is required for absorption with low (dietary) vitamin B12 intake of up to approximately 5 µg, whereas with higher intakes, particularly supplemental, intrinsic factor is not required for absorption.

Deficiency symptoms

Vitamin B12 deficiency is extremely rare and manifests itself most clearly in the megaloblastic anaemia (pernicious anaemia) and neurological disorders.


Vitamin B12


Vitamin B12 is available in power form as 0.1% and 1.0% grade.
Cyanocobalamin is generally crystallized into red, odorless and tasteless needles. It is somewhat soluble in water, soluble in alcohol, insoluble in ether, acetone and chloroform. It decomposes at 210-220°C, without melting. The substance is stable in the hydrated form. Crystalline vitamin B12 or its neutral or slightly acidic solutions are decomposed by light and UV radiation, but are relatively stable to air and heat. Alkalis, strong acids and reducing agents rapidly decompose vitamin B12.
Stability: The stability of the product in formulations is excellent even in the presence of minerals or other aggressive components. Stored in its original packaging at room temperature (max. 25 °C), the product is stable for at least 36 months.


For dietary supplement applications Vitamin B12 is particularly suitable for use in tablets and hard gelatine capsules. The product can be perfectly used in powder preparations, which are dissolved in water prior to use.
To prevent Vitamin B12 deficiency, the product is added to a large number of food products, such as food for babies and small children, food products for athletes, dietetic products, energy drinks, milk powder, multi-vitamin juices, drink powders, confectionary and breakfast cereals.